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Biomolecular Frontiers Research Centre

People

Management committee

Professor Nicki Packer

Professor Nicki Packer (Director)

BSc, PhD (Syd)

Formerly Executive Vice President of the biotechnology company Proteome Systems, Nicki was part of the team that set up the Australian Proteome Analysis Facility at Macquarie. She is a senior editor of Proteomics and holds several patents in glycobiology.

Research interests: The post-translational modification of proteins by sugars (glycomics). This encompasses the role of glycosylation in many systems including the innate immune system, cancer glycomics and improved techniques for analysis of glycoproteins.

Full profile | Contact | Publications: Selected | Full

Professor Ian Paulsen. Photo: Naveid Ali

Professor Ian Paulsen (Deputy Director)

BSc (Hons), PhD (Monash)

An expert in genomics, Ian worked for several years as an investigator for the Institute for Genomic Research in the US, where he led the sequencing of many microbial genomes. He is an ISI Highly Cited Researcher and holds a NSW Life Science Research Award at Macquarie. Ian is currently using genome sequencing, metagenomics and functional genomics to understand how lateral gene transfer in bacteria enables them to adapt to different environmental niches Research interests: Understanding microbial physiology and evolution through global approaches such as genome sequencing, metagenomics, bioinformatics, transcriptomics and proteomics.

Research interests: Understanding microbial physiology and evolution through global approaches such as genome sequencing, metagenomics, bioinformatics, transcriptomics and proteomics.

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Professor Mark Baker. Photo: Naveid Ali

Professor Mark Baker

BSc (Hons), PhD (Macquarie)

Mark has many years' experience managing research programs in academic, industrial and clinical cancer discovery. At Macquarie his team focuses on molecular cell proteomics. An advocate for the commercialisation of Australian biotechnology, he is Chair of the HUPO Nominations Committee.

Research interests: Advanced proteomic technologies, cancer metastasis and how proteases (their receptors, partners and inhibitors) regulate biological processes.

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Emeritus Professor Peter Bergquist. Photo: Naveid Ali

Emeritus Professor Peter Bergquist

MSc (Hons), PhD, DSc (Auckland)

Peter is regarded as an international authority on the cloning and high-level expression of genes coding for enzymes useful to industry. His pioneering work includes developing novel methods for enzyme evolution, and using them to modify thermophile enzymes for improved performance in biofuels research and oil and gas recovery.

He has published extensively on the diversity of culturable and unculturable thermophilic bacteria, and chairs the Ramaciotti Gene Function Analysis Management Committee.

Research interests: The high-level expression of industrially-useful enzymes in fungal hosts, and rapid methods for the field detection of environmental pathogens using isothermal nucleic acids amplification.

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Professor Bill Hancock. Photo: Naveid Ali

Professor Bill Hancock

An expert in clinical proteomics, Bill has worked as a principal scientist at Hewlett Packard Laboratories, and is a former Vice President of Proteomics at ThermoFisher. He was President of the California Separation Science Society for 10 years and is Editor-in-Chief of the Journal of Proteomic Research.

His honours include the Martin Gold Medal in Separation Science (British Chromatographic Society) and the ACS Award in Chromatography.

Research interests: Disease mechanisms; the discovery of potential therapeutic agents by lectin enrichment and proteomic analysis of biological fluids and tissue samples.

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A/Professor Paul Haynes. Photo: Naveid Ali

Professor Paul Haynes

BAppScs (UTS), PhD (Macquarie)

Before joining Macquarie, Paul pursued a research career in the US, including working at the Rockefeller University in New York, and as Associate Professor at the University of Arizona. In 2006 he took up a New South Wales Government Biofirst Fellowship.

He has published 55 scientific papers, is a senior editor for Proteomics, and has four issued patents.

Research interests: Environmental proteomics; applying protein identification and characterisation by mass spectrometry to solve problems in plant biology. Recent projects include: molecular analysis of hot and cold temperature stress in rice plants; heavy metal stress on Sydney rock oysters and amphipods; geographical adaptation to environmental stresses in Pachycladon, an endemic New Zealand plant.

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Mark Molloy. Photo: Naveid Ali

A/Professor Mark Molloy

BSc (Hons), PhD (Biochemistry) (Macquarie)

Mark is a biochemist with 14 years' experience in proteomics. He completed his post-doctoral training at the University of Michigan Medical School. Later he worked in the proteomics R & D group at Pfizer, leading a team to identify biomarkers of new drug entities.

He is currently Director of the Australian Proteome Analysis Facility.

Research interests: Using proteomic technologies for cancer research. This research sits at the interface of biochemistry/cell biology/analytical chemistry/clinical chemistry. The group uses quantitative mass spectrometry and other bioanalytical techniques including electrophoresis and chromatography.

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Helena Nevalainen. Photo: Naveid Ali

Professor Helena Nevalainen

BSc (Genetics), MSc (Genetics), PhD (Genetics) (Helsinki)

Helena is an experienced research manager, and has worked in the biotechnology industry on strain and product development. She has also researched for multinational biotech companies in the US and Finland.

A member of the Academy of Finland as an expert in fungal biotechnology, she has published over 120 papers in refereed journals.

Research interests: Molecular biology and the enzymology of biotechnologically important filamentous fungi. This includes biological control mediated by fungi, fungal proteomics and molecular prospecting of the environment for novel bioactivities and valuable gene products.

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Members

A/Professor Brian Atwell. Photo: Naveid Ali

A/Professor Brian Atwell

Research interests: Cell responses to abiotic factors, using molecular and proteomic techniques to identify key changes when rice plants are chilled, heated or deprived of oxygen.
The effects of elevated CO2 on plant function. In particular, using classical plant physiology to define the experimental conditions under which stress is assessed at the gene level.

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Dr Louise Brown. Photo: Naveid Ali

Dr Louise Brown

BMedSci (Hons), PhD (Syd)

Research interests: Using biophysical spectroscopy techniques to determine the structure of proteins. Conformational changes that accompany the function of proteins. The main technique involves spectroscopic probes or labels that can report on the local environment of the protein.

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Professor Michael Gillings. Photo: Naveid Ali

Professor Michael Gillings

BA, BSc (Hons), PhD (Macquarie)

Seven of his recent publications have been listed as 'must read' or 'recommended' on the Faculty of 1000 website.

Research interests: The exploration of genetic diversity in a range of organisms. Current projects investigate lateral gene transfer in bacteria, population structure in freshwater fish and sharks, and molecular prospecting as a means of recovering novel genes and gene products.

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Professor Ewa Goldys. Photo: Naveid Ali

Professor Ewa Goldys

Ewa's expertise spans the fields of biophotonics, optical characterisation, ultrasensitive detection of analytes, biosensing and bioimaging. She has also developed advanced methods of synthesis and characterisation of fluorescent nanoparticles for applications in fluorescence labelling. Her current research draws on her achievements in materials science and ultrasensitive optical characterisation.

Research interests: The interface of materials science, photonics and biotechnology; optical characterisation, ultrasensitive detection of analytes, biosensing, bioimaging; materials synthesis and characterisation and cathodoluminescence.

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A/Professor Ben Herbert. Photo: Naveid Ali

A/Professor Ben Herbert

Protein separation technologies
Recipient of MQ Vice-Chancellor's Innovation Fellowship

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A/Professot Bridget Mabbutt. Photo: Naveid Ali

A/Professor Bridget Mabbutt

BSc (Chemistry)(Hons), PhD (Chemistry) (Syd)

Research interests: Solving the three-dimensional structures of bio-molecules; the recombinant expression of these molecules, and their function and structure.

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BFRC Sham Nair

Dr Sham Nair

Research Interests: Host-pathogen interactions in invertebrates from genomic and molecular perspectives.  

Current projects: Investigating the generation of diversity in the 185/333 gene family in echinoderms; evolution of immune gene families in deuterostomes from a comparative genomics perspective; molecular basis of re-infection immunity in insects; and the effects of biotic and abiotic stressors on immune reactivity in marine invertebrate.

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Professor David Raftos

Research interests: Evolution of defence: Investigates the internal defence (immune) mechanisms of advanced invertebrtes (ascidians/tunicates) at the cell and molecular biological levels. The overall goals of this works are (i) to determine the ways in which invertebrate animals defence themselves from investion, and (ii) to study the ways in which immune mechanisms have evolved throughout the animal kingdom.

Effects of environmental pollutants on marine invertebrates. Studies the effects of environmental pollutants on the cell and molecular biological systems of common marine invertebrates (ascidians/tunicates). The aims of this research are (i) to identify the cellular systems that are affected by specific pollutants, and determine the ramifications of those cellular effects of the whole animal, and (ii) to develop rapid and reproducible cell or molecular biological assays for the biomonitoring of pollution.

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Professor Shoba Ranganathan. Photo: Naveid Ali

Professor Shoba Ranganathan

Shoba is one the few principal researchers in the world working in several key areas of bioinformatics, to understand biological systems using computational approaches. A former director of the International Society for Computational Biology (ISCB), she is highly acclaimed internationally for her numerous contributions to bioinformatics education.

Research interests: Computational structural biology and comparative genome sequence analysis.

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Dr Anwar Sunna. Photo: Naveid Ali

Dr Anwar Sunna

Senior Research Fellow and Program Leader Manager

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Dr Junior Te'o

Recipient of Vice Chancellor's Innovation Fellowship

Research Interests: a) Recombinant gene/protein expression, development and scale-up production/fermentation using a number of different microbial host systems. b) Synthetic Biology and Biofuels: genetic design, process design/development/production of renewable and sustainable 'drop in' replacements for crude oil in processes associated with current fuels and chemicals.

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A/Professor Robert Willows. Photo: Naveid Ali

A/Professor Rob Willows

Research interests: Chlorophyll biosynthesis and plant hormones; the biological processes in milling wheat to make flour (in association with the CRC for Innovative Grain Food Products).

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Adjuncts

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Dr Belinda Ferrari

University of New South Wales

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Dr Graham Vesey

CEO and Executive Director
Regeneus Animal Health

Affiliated members

Dr Liam Elbourne. Photo: Naveid Ali

Dr Liam Elbourne

Research Fellow

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Dr Susan Fanayan. Photo: Naveid Ali

Dr Susan Fanayan

Research Fellow

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BFRC Karl Hassan

Dr Karl Hassan

Research Fellow

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BFRC David Inglis

Dr David Inglis

Australian Postdoctoral Fellow

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Dr Liisa Kautto. Photo: Naveid Ali

Dr Liisa Kautto

Research Fellow

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Dr Amanda Mackie. Photo: Naveid Ali

Dr Amanda Mackie

Research Assistant, Bioinformatics

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Dr Matthew McKay. Photo: Naveid Ali

Dr Matthew McKay

Postgraduate Fellow

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Dr Leon McQuade. Photo: Naveid Ali

Dr Leon McQuade

Senior Scientific Officer

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Dr Robyn Peterson

Research Fellow

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Dr Nishen Naidoo

Research Fellow

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Dr Sasha Tetu

Research Fellow

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Dr Morten Anderson. Photo: Naveid Ali

Dr Morten Thaysen-Andersen

Visiting Research Fellow
University of Southern Denmark, Odense M, Denmark

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BFRC Sock-Hwee Tan

Dr Sock-Hwee Tan

Research Fellow

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Postgraduates

Hana Bali. Photo: Naveid Ali

Hana Faisal J Bali

Supervisor: Professor Helena Nevalainen
Thesis title: Modification of protease production in the filamentous fungus Trichoderma

Sinead Blaber. Photo: Naveid Ali

Sinead Blaber

Supervisor: Professor Benjamin Herbert
Thesis title: Anti-inflammatory effects of adipose derived cells and secretions

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Katy Breakwell

Supervisors: Professor Ian Paulsen and A/Professor Paul Haynes
Thesis title: Systems Biology Analysis of Secondary Metabolite Production in Biocontra Pseudomonas Species

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Andrew Care

Supervisor: Professor Helena Nevalainen
Thesis title: Development of a Solid Matrix Capture System for Environmental Pathogens and Related Proteins

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Elsa Chacko

Supervisors: Professor Shoba Ranganathan and Professor Helena Nevalainen
Thesis title: Transcript Diversity and Conservation of Alternative Splicing Events by Whole Genome Comparison

Clara Cheah. Photo: Naveid Ali

Clara Wai Yuen Cheah

Supervisors: Professor Nicki Packer and Professor Helena Nevalainen
Thesis title: Sugar-protein interactions: the first line of defence against pathogens

Jenny Chik. Photo: Naveid Ali

Jenny Chik

Supervisor: A/Professor Mark Molloy
Thesis title: Glyoprotein markers of toxicity to chemotherapy in colorectal cancer

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Nicole Cordina

Supervisor: Dr Louise Brown
Thesis title: Pushing the Limits of Paramagnetic Relaxation Enhancement - The Structure of Troponin

Siba Dolai. Photo: Naveid Ali

Sibasish Dolai

Supervisor: A/Professor Mark Molloy
Thesis title: Quantitative proteomics using chemical probes

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Joshua Edwards

Supervisor: A/Professor Brian Atwell
Thesis title: Energy metabolism of germinating rice - regulation of ATP turnover

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Arun Vijay Everest Dass

Supervisor: Professor Nicki Packer
Thesis title: Body fluids: sweet protection against infection?

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Renan Ali Ersoy

Supervisor: Dr Tom Roberts and A/Professor Brian Atwell
Thesis title: Functional expression analyses of serpin genes in Arabidopsis and rice

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Phyllis Farmer

Supervisor: A/Professor Robert Willows
Thesis title: Application of an inplanta transcerit expression system for genetic and biochemical of the structure and function of magnesium chelatase

Daniel Farrugia. Photo: Naveid Ali

Daniel John Farrugia

Supervisors:  Professor Ian Paulsen and A/Professor Bridget Mabbutt
Thesis title: Mechanisms of drug resistance in Acinetobacter

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Sheila Francis

Supervisors: A/Professor Brian Atwell
Thesis title: Identification and expression of serpins in rice

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Gagan Garg

Supervisor: Professor Shoba Ranganathan
Thesis title: Advanced Computational Methods for Mitochondrial DNA Analysis

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Sophia Goodchild

Supervisor: Dr Louise Brown
Thesis title: Structural Studies of CLIC Ion Channels

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Karthikeyan Gunasekaran

Supervisor: Professor Helena Nevalainen
Thesis title: Optimization and Stabilization of an Isothermal Application System

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Andre Hallen

Supervisors: A/Professor Robert Willows and A/Professor Paul Haynes
Thesis title: Amino acid metabolism and mental illness

Cameron Hill. Photo: Naveid Ali

Cameron Hill

Supervisors: A/Professor Benjamin Herbert and A/Professor Paul Haynes
Thesis title: Proteomics of human adipose stem cells

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Kathryn Louise Hughes

Supervisor: Professor Michael Gillings and Emeritus Professor Peter Bergquist
Thesis title: Exploring the bacterial diversity of the McMurdo dry valleys, Antarctica

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Jeff Kelly

Supervisors: A/Professor Brian Atwell
Thesis title: Productivity and water use of Australian forests under climatic change

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Ante Jerkovic

Supervisor: A/Professor Robert Willows and A/Professor Brian Atwell
Thesis title: Biochemical Studies on Wheat Grain to Improve Milling Performance

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Javed Mohammed Khan

Supervisors: Professor Shoba Ranganathan and A/Professor Bridget Mabbutt
Thesis title: A bioformatics approach to structure-based T cell epitope prediction

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Varun Khanna

Supervisor: Professor Shoba Ranganathan
Thesis title: Molecular similarity and diversity analysis of bioactive small molecules using chemoinformatics approaches

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Rajeev Koundinya Nagarajan

Supervisor: Professor Helena Nevalainen
Thesis title: Noval Nitrilases from Filamentous Fungi

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Christoph Krisp

Supervisors: A/Professor Mark Molloy and A/Professor Paul Haynes
Thesis title: Proteomic Analysis of Human Wounds Fluids

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Gaurav Kumar

Supervisor: Professor Shoba Ranganathan
Thesis title: Bioinformatics Integration and Analysis of Omic Data

Ling Lee. Photo: Naveid Ali

Ling Yen Lee

Supervisors:  Professor Nicki Packer, Professor Bill Hancock and A/Professor Paul Haynes
Thesis title: Identification of novel biomarkers for breast cancer

Chee Kent Lim. Photo: Naveid Ali

Chee Lim

Supervisor: Professor Ian Paulsen
Thesis title: Lateral gene transfer and secondary metabolite biosynthesis in Pseudomonas spp

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Michael Mariani

Supervisor: A/Professor Paul Haynes
Thesis title: Development of chip-based Mass Spectrometry Proteomics Techniques

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Juan Martinez-Aguilar

Supervisor: A/Professor Mark Molloy and A/Professor Paul Haynes
Thesis title: Mass Spectrometry Investigation of Plasma Biomarkers for Colon Cancer

Michael Medynskyj. Photo: Naveid Ali

Michael Medynskyj

Supervisors: A/Professor Benjamin Herbert and A/Professor Paul Haynes
Thesis title: Proteomic analysis of adipose-denied stem cells

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Ranjeet Menon

Supervisor: Professor Shoba Ranganathan
Thesis title: Computational Systems Biology of Host-Parasite Interactions

Mehdi Mirzaei. Photo: Naveid Ali

Mehdi Mirzei

Supervisors: A/Professor Paul Haynes and A/Professor Brian Atwell 
Thesis title: Functional proteomics of drought response in rice

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Suja Mohammed

Supervisor: Professor Helena Nevalainen
Thesis title: Prospecting for novel cold active enzymes and the genes from Antarctic microfungi; and isolation and characterisation of a lipase gene from Penicillium expansum

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Jens Mark Moll

Supervisors: A/Professor Bridget Mabbutt and A/Professor Paul Haynes
Thesis title: Structural Organisation of Yeast LSM Complexes

Sridevi Muralidharan. Photo: Naveid Ali

Sridevi Muralidharan

Supervisor: A/Professor Paul Haynes
Thesis title: Proteomic analysis of water stress in grapes

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Jerran Naidoo

Supervisor: Dr Benjamin Herbert
Thesis title: Proteomics of differentiated stem cells

Karlie Neilson. Photo: Naveid Ali

Karlie Ann Neilson

Supervisor: A/Professor Paul Haynes
Thesis title: Analysis of protein complexes in plants

Sarah Randall. Photo: Naveid Ali

Sarah Alison Randall

Supervisor: A/Professor Mark Molloy
Thesis title: Plasma biomarkers in cancer

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Andrew Scafaro

Supervisor: A/Professor Brian Atwell
Thesis title: Physiological and molecular mechanisms of heat stress tolerance in wild and domesticated rice

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Bhumika Shripal Shah

Supervisor: A/Professor Bridget Mabbutt
Thesis title: Structural and functional genomics of acinetobacter baumannii

Prasanth Subramani. Photo: Naveid Ali

Prasanth Subramani

Supervisor: Professor Ian Paulsen
Thesis title: Geonomics of emerging nosocomial pathogens: Burkholderia and acine to bacter species

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Juliet Suich

Supervisor: A/Professor Brian Atwell
Thesis title: Characterising the growth and development of Australian wild rices

Angela Sun. Photo: Naveid Ali

Angela Yu-Hsin Sun

Supervisor: Professor Helena Nevalainen
Thesis title: Expression of obestatin in filamentous fungus Trichoderma reesei

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Visaahini Sureshan

Supervisor: A/Professor Bridget Mabbutt
Thesis title: Protein structures selected from the environmental cassette metagenome

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John Taylor

Supervisor: A/Professor Brian Atwell
Thesis title: Quantifying the architecture of Australian wild rice relatives

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Vignesh Venkatakrishnan

Supervisor: Professor Nicki Packer
Thesis title: Interactions of microbial pathogens with sputum from cystic fibrosis patients.

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Rebecca Webster

Supervisor: A/Professor Benjamin Herbert
Thesis title: The role of adipose stem cells in osteoarthritis

Katherine Wongtrakul-Kish. Photo: Naveid Ali

Katherine Wongtrakul-Kish

Supervisors: Professor Nicki Packer and A/Professor Ben Herbert
Thesis title: Carbohydrate-specific markers of breast cancer